Elucidation of the <i>in vivo</i> pharmacological actions of different bone-protecting agents by intravital imaging technology
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- Kikuta Junichi
- Dept. Immunol. and Cell Biol., Osaka Univ.
Bibliographic Information
- Other Title
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- 生体イメージングによる骨疾患治療薬の<i>in vivo </i>薬理作用の解明
Abstract
<p>We originally established an advanced imaging system to visualize living bone tissues using intravital two-photon microscopy, and revealed the dynamics of osteoclastic bone resorption which was finely regulated by cell-cell contact with bone-forming osteoblasts. By means of this system, we could grasp the real mode of actions of active vitamin D and parathyroid hormone (PTH) on bone metabolism. Furthermore, intravital imaging revealed that various biologic DMARDs acted at specific therapeutic points during bone destruction, with different efficacies. This technique facilitates investigation of cellular dynamics in the physiology and pathogenesis of bone disorders in vivo, and would thus be useful for evaluating the efficacy of novel anti-bone resorptive drugs currently developed in the world.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 94 (0), 1-YAL2-, 2021
Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390568916164467840
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- NII Article ID
- 130008001341
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed