Production of methylglyoxal, a highly reactive dicarbonyl compound, and its detoxification imbalance in diabetes complications

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  • Tsuji Takehiko
    Tsuji Oil Mills Co., Ltd. OKUISE Bio-Science Center, Non-profit Inc.
  • Umemoto Yoshiaki
    Tsuji Oil Mills Co., Ltd.
  • Matuo Yushi
    OKUISE Bio-Science Center, Non-profit Inc. Human Health Science, Graduate School of Med. & Faculty of Medicine, Kyoto University

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  • 反応性の高いジカルボニル基を持つメチルグリオキサール（MGO）の生成と解毒、そして糖尿病合併症
  • ハンノウセイ ノ タカイ ジカルボニルキ オ モツ メチルグリオキサール(MGO)ノ セイセイ ト ゲドク 、 ソシテ トウニョウビョウ ガッペイショウ

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Abstract

In this article, we emphasize that: (i) methylglyoxal (MGO) is mainly formed as a byproduct of glycolysis and, under physiological circumstances, detoxified by the glyoxalases (GLXase) and glutathione (GSH) systems; (ii) the imbalance between the formation of MGO and its detoxification is linked to the rapid reaction with guanidyl residue, forming MG-H1/CEA; (iii) the MGO modification/ glycation is subsequently leading to the vascular complications in diabetes.

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