Development of Selective Reactions Using Ball Milling

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  • Kubota Koji
    Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University
  • Ito Hajime
    Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University

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  • ボールミルの特徴を活かした新しい選択的反応の開発
  • ボールミル ノ トクチョウ オ イカシタ アタラシイ センタクテキ ハンノウ ノ カイハツ

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<p>In recent years, solvent-less mechanochemical organic reactions using ball milling have come to the forefront of organic synthesis as cleaner and sustainable synthetic alternatives to conventional solution-based approaches. Apart from the environmental benefits, mechanochemical approaches potentially enable access to novel chemical space that has reactivities and selectivities different from those of conventional solution-based reactions. In this context, we have focused on the development of new solid-state organic transformations using mechanochemistry. We recently succeeded in developing broadly applicable solid-state palladium-catalyzed cross-coupling reactions under mechanochemical conditions. The key finding of these studies is that alkene additives can cat as dispersants for the palladium-based catalyst and also as stabilizer for the active monomeric palladium(0) species, thus facilitating these challenging solid-state bond forming reactions. In addition, we have discovered a conceptually new redox system, in which electrons are transferred from distorted piezoelectric materials in the solid-state to trigger organic transformations. This ‘mechanoredox’ system represents a unique solid-state approach that is complementary to photoredox reactions in solution.</p>

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