A case of malignant peripheral nerve sheath tumor of the mandibular gingiva
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- MAKISHI Shoko
- Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of the Ryukyus
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- MATAYOSHI Akira
- Department of Oral and Maxillofacial Surgery, University of the Ryukyus Hospital
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- MIYAMOTO Sho
- Department of Oral and Maxillofacial Surgery, University of the Ryukyus Hospital
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- HIRANO Husahiro
- Department of Oral and Maxillofacial Surgery, University of the Ryukyus Hospital
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- NAKASONE Toshiyuki
- Department of Oral and Maxillofacial Surgery, University of the Ryukyus Hospital
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- NAKAMURA Hiroyuki
- Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of the Ryukyus Department of Oral and Maxillofacial Surgery, University of the Ryukyus Hospital
Bibliographic Information
- Other Title
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- 下顎歯肉に発生した悪性末梢神経鞘腫瘍の1例
- カガク シニク ニ ハッセイ シタ アクセイ マッショウ シンケイ サヤ シュヨウ ノ 1レイ
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Abstract
<p>Malignant peripheral nerve sheath tumors (MPNSTs) are very rare malignant neoplasia that arise from the peripheral nervous system and show nerve sheath differentiation. We report a case of primary malignant peripheral nerve sheath tumor of the mandibular gingiva.</p><p> A 53-year-old male was referred to our hospital presenting with a mass and pain in the mandibular gingiva. He had no appreciable disease and paralysis of the lower lip.</p><p> Computed tomography showed resorption of the mandible but no obvious lymph node metastasis.</p><p> Biopsy revealed a possible invasive unusual neuroectodermal tumor. Surgical resection was performed and the frozen section showed negative margins.</p><p> Histology revealed atypical spindle cells with clear chromatin and clear nucleolus which had proliferated and loosely infiltrated, but the cell boundaries were unclear. Immunohistochemical staining showed positive results for S-100 protein, p53, and vimentin, but negative results for pan-cytokeratin (AE1 / AE3), Melan A, and desmin. The Ki-67 labeling index was 10%. Accordingly, we diagnosed a low-grade peripheral nerve sheath tumor of the mandibular gingiva.</p><p> There were no signs of recurrence or metastasis at two years postoperatively. MPNSTs have poor prognoses and require careful follow-up.</p>
Journal
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- Japanese Journal of Oral and Maxillofacial Surgery
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Japanese Journal of Oral and Maxillofacial Surgery 67 (3), 194-199, 2021-03-20
Japanese Society of Oral and Maxillofacial Surgeons
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Details 詳細情報について
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- CRID
- 1390569557086331648
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- NII Article ID
- 130008040237
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- NII Book ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL BIB ID
- 031379910
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed