Non-invasive quantification of liver damage by a novel application for statistical analysis of ultrasound signals

DOI IR HANDLE Web Site
  • Yakoshi Yuta
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Kudo Daisuke
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Toyoki Yoshikazu
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Isido Keinosuke
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Kimura Norihisa
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Wakiya Taiichi
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Sakuraba Shingo
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
  • Yoshizawa Tadashi
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
  • Sakamoto Yoshiyuki
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Kijima Hiroshi
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
  • Hakamada Kenichi
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine

Bibliographic Information

Other Title
  • 超音波信号の統計学的解析技術による，肝障害の非侵襲的定量

Search this article

Abstract

Aim: Hepatic steatosis is a major cause of steatohepatitis and is observed in several diffuse liver diseases. We studied the efficacy of a novel ultrasound application, acoustic structure quantification (ASQ), for analyzing the amount of fat deposition in the liver parenchyma.<br> Methods: Forty-three patients who received a hepatectomy at our institution participated in this study. An ultrasound machine equipped with a software application for ASQ was used to detect steatosis prior to surgery. Non-tumoral liver parenchyma obtained by hepatectomy was pathologically evaluated according to the three-grade system.<br> Results: Histopathologically, twenty-three patients did not present steatosis, seventeen presented grade 1, and the remaining three presented grade 2 steatosis. The median “focal disturbance ratio” (FD-ratio), a representative index obtained by ASQ, decreased with the steatosis grade, from 0.157 (range: 0.039-0.410) at steatosis grade 0, 0.085 (range: 0.021-0.159) at steatosis grade 1, and 0.039 (range: 0.021-0.048) at steatosis grade 2. There were significant differences in the FD-ratio between steatosis grades 0 and 1 and between steatosis grades 0 and 2 (p = 0.001 and p = 0.007, respectively).<br> Conclusions: ASQ can be useful during a quantitative examination of the fat accumulation in the liver parenchyma and offers a reliable marker for the early detection of liver injury.

Journal

  • Hirosaki Medical Journal

    Hirosaki Medical Journal 65 (2-4), 199-208, 2014

    Hirosaki University Graduate School of Medicine,Hirosaki Medical Society

Keywords

Details 詳細情報について

Report a problem

Back to top