Clinical efficacy of the reduced form of coenzyme Q<sub>10</sub> (ubiquinol)

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  • 還元型コエンザイムQ<sub>10</sub> による臨床効果（特集　「バイオファクターについて考える～生合成・代謝と機能性発現機構を再考する～」（第71 回大会シンポジウムⅠ））
  • 特集 バイオファクターについて考える : 生合成・代謝と機能性発現機構を再考する(第71回大会シンポジウム) 還元型コエンザイムQ₁₀による臨床効果
  • トクシュウ バイオファクター ニ ツイテ カンガエル : セイゴウセイ ・ タイシャ ト キノウセイ ハツゲン キコウ オ サイコウ スル(ダイ71カイ タイカイ シンポジウム) カンゲンガタ コエンザイム Q ₁ ₀ ニ ヨル リンショウ コウカ

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Abstract

In place of the oxidized form of coenzyme Q10 (ubiquinone), which was used to study coenzyme Q10 for a long period of time, the reduced form of coenzyme Q10 (ubiquinol) which is an biological active form, has been used in clinical studies since the start of its industrial production in 2000s. <br> Ubiquinol-related diseases are mostly associated with reduced body concentrations of ubiquinol. These diseases are shown to be associated with SNP (a single nucleotide polymorphism) in the ubiquinol biosynthetic genes, and the central nervous system is affected in nearly half of the diseases. In a double-blind placebo-controlled study in patients with Parkinson’s disease, ubiquinol at a dose of 300 mg/day was effective when used in combination with dopamine. In double-blind placebo-controlled studies in healthy individuals, ubiquinol was used at doses of 100 to 150 mg/day. In a study in fatigable healthy individuals, ubiquinol caused reduced fatigue, improved sleepiness, and elevated motivation in the subjects. In healthy individuals with mild seasonal allergy-like symptoms, ubiquinol reduced itchy eyes and nose and improved sleep. <br> A community-based clinical study evaluating the safety and efficacy of long-term use of ubiquinol demonstrated long-term safety as well as improvement in subjective QOL and cognitive function. It was also suggested that interruption of ubiquinol intake may result in reduced blood concentrations of ubiquinol and subjective QOL. <br> In conclusion, ubiquinol is suggested to improve various clinical symptoms and, therefore, its clinical application is expected.

Journal

  • VITAMINS

    VITAMINS 94 (5-6), 319-323, 2020-06-25

    THE VITAMIN SOCIETY OF JAPAN

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