Pyrrolactams from Marine Sponge Stylissa massa Collected from Myanmar and Their Anti-Vpr Activities
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- Win Nwet Nwet
- Institute of Natural Medicine, University of Toyama
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- Kodama Takeshi
- Institute of Natural Medicine, University of Toyama
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- Aye Aung Aung
- Department of Marine Sciences, Myeik University
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- Lae Khine Zar Wynn
- Department of Chemistry, University of Yangon
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- Ngwe Hla
- Department of Chemistry, University of Yangon
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- Han Nang Mya
- Department of Marine Sciences, Myeik University
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- Abe Ikuro
- Graduate School of Pharmaceutical Sciences, The University of Tokyo Collaborative Research Institute for Innovative Microbiology, The University of Tokyo
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- Morita Hiroyuki
- Institute of Natural Medicine, University of Toyama
書誌事項
- タイトル別名
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- Pyrrolactams from Marine Sponge <i>Stylissa massa</i> Collected from Myanmar and Their Anti-Vpr Activities
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説明
<p>A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa massa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 µM and its potency was comparable to that of positive control damnacanthal.</p>
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 69 (7), 702-705, 2021-07-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390570022236694656
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- NII論文ID
- 130008060016
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 031534676
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- PubMed
- 34193719
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可