Influence of trace elements within normal physiological range on neutrophil basal reactive oxygen species production in the Japanese general population

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  • Ito Haruyuki
    Department of Social Medicine, Hirosaki University Graduate School of Medicine Department of Health Science, Aomori University of Health and Welfare
  • Takahashi Ippei
    Department of Social Medicine, Hirosaki University Graduate School of Medicine
  • Matsuzaka Masashi
    Department of Social Medicine, Hirosaki University Graduate School of Medicine
  • Lee Sangun
    Department of Health Science, Aomori University of Health and Welfare
  • Itai Kazuyoshi
    Department of Hygiene and Preventive Medicine, Iwate medical University
  • Fukui Shinji
    Department of Social Medicine, Hirosaki University Graduate School of Medicine Shokei Gakuin University
  • Hamada Naoko
    Department of Social Medicine, Hirosaki University Graduate School of Medicine Nursing School, National Defense Medical College
  • Saito Yuriko
    Department of Social Medicine, Hirosaki University Graduate School of Medicine Department of Plastic and Reconstructive Surgery, Hirosaki University of Graduate School of Medicine
  • Umeda Takashi
    Department of Social Medicine, Hirosaki University Graduate School of Medicine
  • Nakaji Shigeyuki
    Department of Social Medicine, Hirosaki University Graduate School of Medicine

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Other Title
  • 生体内必須微量元素が好中球の活性酸素種産生量に及ぼす影響

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Abstract

Objective: We investigated the relationship between trace element concentrations and neutrophil basal reactive oxygen species (ROS) production capability among the Japanese general population.<br> Subjects and methods: Subjects of the current study were 606 participants (225 males and 381 females) who had participated in the Iwaki Health Promotion Project 2005. Body mass index, biochemical blood examination, neutrophil basal ROS production and serum concentrations of trace element (Copper (Cu), Zinc (Zn), Iron (Fe), Selenium (Se) ) were measured. Each trace element was divided into 4 quartiles according to the concentration, and the neutrophil basal ROS production of each group was compared and analyzed. Moreover, the relationship between the concentration and neutrophil basal ROS production capability was assessed using a multiple linear regression analysis.<br> Results: For both males and females, a tendency to low neutrophil ROS production associated with higher Se serum concentration was observed. On the other hand, no significant correlation was observed between the Cu, Zn and Fe concentrations and neutrophil basal ROS production capability.<br> Conclusion: In conclusion, serum Se relieves oxidative stress through inhibiting neutrophil ROS production within a physiological range. On the other hand, our results suggested that neutrophil ROS production was unaffected by Cu, Zn and Fe concentrations within the normal physiological range.

Journal

  • Hirosaki Medical Journal

    Hirosaki Medical Journal 63 (2-4), 85-95, 2012

    Hirosaki University Graduate School of Medicine,Hirosaki Medical Society

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