Development of Novel Targeted Drug Delivery Systems Using Amino Acid Modification

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  • Katsumi Hidemasa
    Department of Biopharmaceutics, Kyoto Pharmaceutical University
  • Yamashita Shugo
    Department of Biopharmaceutics, Kyoto Pharmaceutical University Department of Pharmacokinetics, Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts
  • Morishita Masaki
    Department of Biopharmaceutics, Kyoto Pharmaceutical University
  • Yamamoto Akira
    Department of Biopharmaceutics, Kyoto Pharmaceutical University

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  • アミノ酸修飾を利用したターゲティング型ドラッグデリバリーシステムの開発
  • アミノサン シュウショク オ リヨウ シタ ターゲティングガタ ドラッグデリバリー システム ノ カイハツ

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Abstract

<p>Targeted drug delivery system plays an important role to achieve a satisfactory therapeutic outcome. To obtain the efficient treatment of bone and kidney diseases, we developed bone or kidney-targeted delivery systems using amino acid modifications. In bone-targeting, we developed highly potent nano-carriers targeted to bone using L-aspartic acid modification for their use as therapeutic agents for bone metastasis. In kidney-targeting, we developed L-serine-modified nano-carrier as a potent renal targeting drug carrier for the treatment of kidney diseases.</p><p>In this article, these recent developments in bone or kidney-targeted delivery systems using amino acid modifications are summarized.</p>

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