Aging studies using SMP30 knockout mice that are defective in vitamin C biosynthesis

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  • Ishigami Akihito
    Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology

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Other Title
  • ビタミンC 合成不全マウスを用いた老化研究―健康長寿を目指して―（特集　第1 回ビタミンC 研究委員会シンポジウム「今，ビタミンC が面白い」）
  • 特集 第1回ビタミンC研究委員会シンポジウム「今,ビタミンCが面白い」 ビタミンC合成不全マウスを用いた老化研究 : 健康長寿を目指して
  • トクシュウ ダイ1カイ ビタミン C ケンキュウ イインカイ シンポジウム 「 イマ,ビタミン C ガ オモシロイ 」 ビタミン C ゴウセイ フゼン マウス オ モチイタ ロウカ ケンキュウ : ケンコウ チョウジュ オ メザシテ

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Description

Humans are unable to synthesize vitamin C (VC). Therefore, if we do not take VC from diet, we will fall into VC deficiency, causing various physical disorders and then eventually develop scurvy and death. To clarify the relationship between VC and aging, we developed SMP30 knockout mice that are defective in vitamin C biosynthesis. Using SMP30 knockout mice, we revealed that long-term shortage of VC shortened their lifespan. Moreover, we found that VC deficiency caused muscle atrophy and a deterioration in physical performance. Like mice, our longevity might be shortened if VC deficiency continues for a long time. To avoid this undesirable thing, we have to take enough VC from fresh vegetables and fruits, and beverages and supplements containing VC.

Journal

  • VITAMINS

    VITAMINS 94 (7), 393-396, 2020-07-25

    THE VITAMIN SOCIETY OF JAPAN

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