Regulation of Liquid-Liquid Phase Separation by Molecular Chaperones

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  • KAWAGOE SOICHIRO
    Graduate School of Chemical Sciences and Engineering, Hokkaido University Graduate School of Medical Sciences, Tokushima University
  • MORI EIICHIRO
    Department of Future Basic Medicine, Nara Medical University
  • SAIO TOMOHIDE
    Graduate School of Medical Sciences, Tokushima University Institute of Advanced Medical Sciences, Tokushima University

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Other Title
  • 分子シャペロンによる液–液相分離制御
  • ブンシ シャペロン ニ ヨル エキ-エキソウ ブンリ セイギョ

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Description

<p>Molecular chaperones have been extensively studied as mediators in protein folding and quality control but are recently attracting increasing attention as regulators of liquid-liquid phase separation (LLPS). In this review, we summarize recent studies regarding molecular chaperones involved in LLPS regulation. We also provide a brief introduction of biophysical and structural studies on molecular chaperones in protein folding that depict how the molecular chaperones recognize client proteins and alter the folding process. Although little is known about the mechanism of regulation of LLPS, the understanding of molecular chaperones in protein folding will provide hints for LLPS regulation.</p>

Journal

  • Thermal Medicine

    Thermal Medicine 37 (2), 31-44, 2021-07-05

    Japanese Society for Thermal Medicine

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