Rapid Determination of 7-Hydroxycoumarin Using a Nanogold/Poly-thionine Modified Glass Carbon Electrode

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  • ZHENG Yanjie
    Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University Nano Biomedical Technology Research Center, Fujian Medical University Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University
  • ZHONG Tianhua
    Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanograpy, Ministry of Natural Resources
  • XU Yichun
    Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University
  • CHEN Li
    Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University
  • YIN Xinyang
    Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University
  • LIN Fei
    Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University
  • DAI Qiang
    Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University
  • WENG Shaohuang
    Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University Nano Biomedical Technology Research Center, Fujian Medical University
  • LIN Xinhua
    Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University Nano Biomedical Technology Research Center, Fujian Medical University

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<p>This paper presents a novel voltametric procedure for 7-hydroxycoumarin determination by using a nanogold/poly-thionine modified electrode. The characterization of nanomaterials has been conducted by scanning electron microscopy (SEM) and electrochemical methods. The electrochemical sensing of 7-hydroxycoumarin was investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). By combining the excellent electrocatalytic property of nanogold and polymer materials, this sensor shows an improved electrochemical response for 7-hydroxycoumarin detection with a good linear relationship in the range of 5.0 × 10−6 – 3.0 × 10−5 mol L−1; the detection limit was 1.0 × 10−6 mol L−1. This method solves the problem that 7-hydroxycoumarin cannot be accurately quantified on a bare glassy carbon electrode, and also improves the detection sensitivity. This is expected to play a huge potential in the quantitative analysis of quality control, plasma concentration monitoring and mechanism research in vivo of this drug.</p>

Journal

  • Analytical Sciences

    Analytical Sciences 37 (8), 1073-1079, 2021-08-10

    The Japan Society for Analytical Chemistry

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