Prevention of toxicity in the next generation caused by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: recovery effect of α-lipoic acid on sexual immaturity

DOI
  • YUAN Ming
    Graduate School of Pharmaceutical Sciences, Kyushu University
  • SANO Hiroe
    Graduate School of Pharmaceutical Sciences, Kyushu University
  • NISHIDA Kyoko
    Graduate School of Pharmaceutical Sciences, Kyushu University
  • KOGA Takayuki
    Daiichi University of Pharmacy
  • TAKEDA Tomoki
    Graduate School of Pharmaceutical Sciences, Kyushu University Japan Bioassay Research Center
  • TANAKA Yoshitake
    Graduate School of Pharmaceutical Sciences, Kyushu University
  • ISHII Yuji
    Graduate School of Pharmaceutical Sciences, Kyushu University

Bibliographic Information

Other Title
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin次世代毒性の予防：児の性未成熟に対するα-リポ酸の回復効果

Abstract

<p>Maternal exposure to TCDD was suggested to attenuate LH production during the perinatal stage, and the supplementation of α-lipoic acid to TCDD-exposed pregnant dams showed a recovery effect on the attenuated LH production during the gestational period. Therefore, it was expected that α-lipoic acid supplementation would have a recovery effect on the retardation of the male offspring’s sexual immaturity induced by maternal exposure to TCDD. This study suggests that maternal supplementation with α-lipoic acid has a restoring effect on the decreased SDN-POA volume, which is an indicator of sexual differentiation in male offspring.</p>

Journal

Details 詳細情報について

  • CRID
    1390570486221670784
  • NII Article ID
    130008073655
  • DOI
    10.14869/toxpt.48.1.0_o-11
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

Report a problem

Back to top