Arsenite enhances the anti-tumor activity of photodynamic therapy using talaporfin sodium against U251 glioblastoma cell line
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- SHIMIZU Yuuri
- Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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- YANO Yuka
- Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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- FUJII Kazuna
- Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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- TAKAHASHI Tsutomu
- Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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- TSUNEOKA Yayoi
- Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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- SHINODA Yo
- Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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- AKIMOTO Jiro
- Department of Neurosurgery, Tokyo Medical University
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- FUJIWARA Yasuyuki
- Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Bibliographic Information
- Other Title
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- U251神経膠芽腫細胞株における光線力学療法の抗腫瘍効果に対する亜ヒ酸の増強効果
Abstract
<p>Glioblastoma is the most aggressive type of solid cancer that begins within the brain. We previously demonstrated that photodynamic therapy using talaporfin sodium (TS-PDT) treatment exhibits anti-tumor activity against glioblastoma. In this study, we found that sodium arsenite selectively decreased the cell viability of U251 glioblastoma cell line. Moreover, arsenite enhanced the anti-tumor activity of TS-PDT in the cells. These results suggest that arsenite has the potential to exhibit anti-tumor activity against U251 glioblastoma cell line and enhance the anti-tumor effect of TS-PDT.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 48.1 (0), P-14S-, 2021
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390570486221673984
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- NII Article ID
- 130008073693
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed