Evaluation of Convulsion Potential in Rats Using Motor Evoked Potentials
-
- KUGA Kazuhiro
- Takeda Pharmaceutical Company Ltd.
-
- OZAKI Harushige
- Takeda Pharmaceutical Company Ltd.
-
- FUJIKI Minoru
- Oita University
Bibliographic Information
- Other Title
-
- 運動誘発電位を用いたラットにおける催痙攣ポテンシャルの評価
Abstract
<p>Convulsion causes significant impact on drug development, therefore, appropriate evaluation is important for the development of compounds with convulsion potential. The aim of this study was to evaluate the convulsion potential after drug administration by using motor evoked potentials (MEP) in rats. Rats were dosed with 3 convulsants or 1 non-convulsant, and then, MEP was measured under anesthesia. As a result, convulsant-related effects were observed in MEP. It suggests MEP is useful for evaluating drug-induced convulsions in rats.</p>
Journal
-
- Annual Meeting of the Japanese Society of Toxicology
-
Annual Meeting of the Japanese Society of Toxicology 48.1 (0), P-34-, 2021
The Japanese Society of Toxicology
- Tweet
Details 詳細情報について
-
- CRID
- 1390570486221776896
-
- NII Article ID
- 130008073725
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- CiNii Articles
-
- Abstract License Flag
- Disallowed