Evaluation of Convulsion Potential in Rats Using Motor Evoked Potentials

DOI

Bibliographic Information

Other Title
  • 運動誘発電位を用いたラットにおける催痙攣ポテンシャルの評価

Abstract

<p>Convulsion causes significant impact on drug development, therefore, appropriate evaluation is important for the development of compounds with convulsion potential. The aim of this study was to evaluate the convulsion potential after drug administration by using motor evoked potentials (MEP) in rats. Rats were dosed with 3 convulsants or 1 non-convulsant, and then, MEP was measured under anesthesia. As a result, convulsant-related effects were observed in MEP. It suggests MEP is useful for evaluating drug-induced convulsions in rats.</p>

Journal

Details 詳細情報について

  • CRID
    1390570486221776896
  • NII Article ID
    130008073725
  • DOI
    10.14869/toxpt.48.1.0_p-34
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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