Relationship between aromatase inhibitory activity in a new chemical entity and reproductive ability in rats
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- YOSHIDA Shiori
- Product Safety and Pharmaceutical Research Group, Research Center, Nihon Nohyaku Co., Ltd.
Bibliographic Information
- Other Title
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- アロマターゼ活性阻害作用が繁殖機能に及ぼす影響
Abstract
<p>We studied toxic relationship between aromatase inhibitory activity in a novel compound and its effect on reproductive ability in rats.</p><p>The compound was orally administered repeatedly to non-pregnant and pregnant rats for 14 or 16 days. Animals in high dose group showed their estrus cycle ceasing and decreased body weight gain. Plasma estradiol concentration decreased. Delayed delivery and increased neonatal mortality were observed.</p><p>These reproductive abnormality would depend on the decreased plasma estradiol concentration induced by the aromatase inhibitory activity in the compound.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 48.1 (0), S15-4-, 2021
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390570486221785088
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- NII Article ID
- 130008073780
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed