Relationship between aromatase inhibitory activity in a new chemical entity and reproductive ability in rats

DOI
  • YOSHIDA Shiori
    Product Safety and Pharmaceutical Research Group, Research Center, Nihon Nohyaku Co., Ltd.

Bibliographic Information

Other Title
  • アロマターゼ活性阻害作用が繁殖機能に及ぼす影響

Abstract

<p>We studied toxic relationship between aromatase inhibitory activity in a novel compound and its effect on reproductive ability in rats.</p><p>The compound was orally administered repeatedly to non-pregnant and pregnant rats for 14 or 16 days. Animals in high dose group showed their estrus cycle ceasing and decreased body weight gain. Plasma estradiol concentration decreased. Delayed delivery and increased neonatal mortality were observed.</p><p>These reproductive abnormality would depend on the decreased plasma estradiol concentration induced by the aromatase inhibitory activity in the compound.</p>

Journal

Details 詳細情報について

  • CRID
    1390570486221785088
  • NII Article ID
    130008073780
  • DOI
    10.14869/toxpt.48.1.0_s15-4
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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