Mechanisms of toxicity caused by carbon nanotubes

DOI
  • YAMAGUCHI Shin-Ichiro
    Laboratory of Immunology and Microbiology, College of Pharmaceutical Science, Ritsumeikan University
  • MORITA Masanobu
    Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine
  • ITO Fumiya
    Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine CREST, Japan Science and Technology Agency (JST)
  • XIE Qilin
    Laboratory of Immunology and Microbiology, College of Pharmaceutical Science, Ritsumeikan University
  • TOYOKUNI Shinya
    Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine CREST, Japan Science and Technology Agency (JST)
  • NAKAYAMA Masafumi
    Laboratory of Immunology and Microbiology, College of Pharmaceutical Science, Ritsumeikan University PRESTO, JST

Bibliographic Information

Other Title
  • カーボンナノチューブによる毒性発現機構

Abstract

<p>Multi-walled carbon nanotubes (MWCNTs), the highly representative products of nanotechnology, induce macrophage cell death and NLRP3 inflammasome activation leading to granuloma and mesothelioma in rodents; however, it remains unknown how macrophages recognize MWCNTs. By a target screening of phagocyte receptors, we here demonstrated that T cell immunoglobulin mucin 4 (Tim4) and Tim1 recognize MWCNTs. Using Tim4-/- Tim1-/- mice, we revealed that Tim4 is involved in MWCNT-associated pathogenesis. Taken together, these results indicate that Tim4 and Tim1 are receptors for MWCNTs.</p>

Journal

Details 詳細情報について

  • CRID
    1390570486222896128
  • NII Article ID
    130008073627
  • DOI
    10.14869/toxpt.48.1.0_o-4
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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