Chronotoxicity of 6-mercaptoprine in mice
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- MIYAZAWA Masayuki
- Yokohama University of Pharmacy
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- TERUI Fuka
- Yokohama University of Pharmacy
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- KATSURAGAWA Shinichi
- Yokohama University of Pharmacy
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- KAGAWA-TANAKA Toshiko
- Yokohama University of Pharmacy
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- KAWAMURA Ikuo
- Yokohama University of Pharmacy
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- YOKOTA Satoshi
- National Institute of Occupational Safety and Health Japan
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- YOSHIOKA Hiroki
- The University of Texas Health Science at Houston
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- KANEKO Masahiro
- Yokohama University of Pharmacy
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- MIURA Nobuhiko
- Yokohama University of Pharmacy
Bibliographic Information
- Other Title
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- 6-メルカプトプリンに対するマウスの感受性時刻差
Abstract
<p>The chronotoxicity of 6-MP was investigated using mice. When mice were received single intraperitoneal administration of 6-MP at different administration timings, we obtained the results showing that the severity of toxicity of 6-MP was strong from evening to night (body weight change and lethality were used as indicators). Since the dosage form of 6-MP is only a powdered form in Japan, the occupational exposure of 6-MP to healthcare workers, including pharmacists, has become a problem. Our present data can be a basic finding to prevent health care workers from 6-MP health problems.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 48.1 (0), O-19-, 2021
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390570486222899328
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- NII Article ID
- 130008073661
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed