Investigation of the mechanisms underlying hepatocarcinogenesis of 1,3-dichloro-2-propanol using <i>gpt</i> delta transgenic rats
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- TAKASU Shinji
- Division of Pathology, National Institute of Health Sciences
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- ISHII Yuji
- Division of Pathology, National Institute of Health Sciences
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- NAKAMURA Kenji
- Division of Pathology, National Institute of Health Sciences
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- NAMIKI Moeka
- Division of Pathology, National Institute of Health Sciences
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- NOHMI Takehiko
- Division of Pathology, National Institute of Health Sciences
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- OGAWA Kumiko
- Division of Pathology, National Institute of Health Sciences
Bibliographic Information
- Other Title
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- <i>gpt</i> deltaラットを用いた1,3-dichloro-2-propanolの肝発がん機序の検索
Description
<p>1,3-Dichloro-2-propanol (1,3-DCP), a food contaminant, is carcinogenic in rats. To understand the mechanisms of 1,3-DCP-induced hepatocarcinogenesis, we examined histopathology, in vivo mutagenicity and preneoplastic lesions in the livers of gpt delta rats treated with 1,3-DCP under carcinogenic conditions. gpt mutant frequencies were significantly increased in 1,3-DCP-treated rats, suggesting the involvement of genotoxic mechanisms in hepatocarcinogenecity of 1,3-DCP. On the other hand, lack of increases in GST-P+ foci was observed and will be discussed along with further investigations.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 48.1 (0), P-19-, 2021
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390570486222914560
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- NII Article ID
- 130008073737
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed