Investigation of the mechanisms underlying hepatocarcinogenesis of 1,3-dichloro-2-propanol using <i>gpt</i> delta transgenic rats

DOI
  • TAKASU Shinji
    Division of Pathology, National Institute of Health Sciences
  • ISHII Yuji
    Division of Pathology, National Institute of Health Sciences
  • NAKAMURA Kenji
    Division of Pathology, National Institute of Health Sciences
  • NAMIKI Moeka
    Division of Pathology, National Institute of Health Sciences
  • NOHMI Takehiko
    Division of Pathology, National Institute of Health Sciences
  • OGAWA Kumiko
    Division of Pathology, National Institute of Health Sciences

Bibliographic Information

Other Title
  • <i>gpt</i> deltaラットを用いた1,3-dichloro-2-propanolの肝発がん機序の検索

Description

<p>1,3-Dichloro-2-propanol (1,3-DCP), a food contaminant, is carcinogenic in rats. To understand the mechanisms of 1,3-DCP-induced hepatocarcinogenesis, we examined histopathology, in vivo mutagenicity and preneoplastic lesions in the livers of gpt delta rats treated with 1,3-DCP under carcinogenic conditions. gpt mutant frequencies were significantly increased in 1,3-DCP-treated rats, suggesting the involvement of genotoxic mechanisms in hepatocarcinogenecity of 1,3-DCP. On the other hand, lack of increases in GST-P+ foci was observed and will be discussed along with further investigations.</p>

Journal

Details 詳細情報について

  • CRID
    1390570486222914560
  • NII Article ID
    130008073737
  • DOI
    10.14869/toxpt.48.1.0_p-19
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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