Impact of preoperative low prognostic nutritional index and high intramuscular adipose tissue content on outcomes of patients with oral squamous cell carcinoma

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  • YOSHIMURA Takuya
    Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Kagoshima University Graduate School of Medical and Dental Sciences
  • SUZUKI Hajime
    Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Kagoshima University Graduate School of Medical and Dental Sciences
  • TAKAYAMA Hirotaka
    Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Kagoshima University Graduate School of Medical and Dental Sciences
  • HIGASHI Shotaro
    Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Kagoshima University Graduate School of Medical and Dental Sciences
  • HIRANO Yuka
    Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Kagoshima University Graduate School of Medical and Dental Sciences
  • TEZUKA Masahiro
    Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Kagoshima University Graduate School of Medical and Dental Sciences
  • ISHIDA Takayuki
    Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Kagoshima University Graduate School of Medical and Dental Sciences
  • NAKAMURA Yasunori
    Department of Oral Surgery, National Hospital Organization Kagoshima Medical Center
  • NOZOE Etsuro
    Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Kagoshima University Graduate School of Medical and Dental Sciences
  • NAKAMURA Norifumi
    Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Kagoshima University Graduate School of Medical and Dental Sciences

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Other Title
  • 口腔扁平上皮癌患者の予後に対する術前低予後栄養指数および高筋肉内脂肪含有量の影響
  • コウコウ ヘンペイ ジョウヒ ガン カンジャ ノ ヨゴ ニ タイスル ジュツゼン テイヨゴ エイヨウ シスウ オヨビ コウキンニク ナイ シボウ ガンユウリョウ ノ エイキョウ

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Abstract

<p>The impact of preoperative malnutrition and sarcopenia on survival in oral squamous cell carcinoma (OSCC) patients remains controversial. We investigated the effects of preoperative nutritional status and abnormalities in body composition on the mortality of OSCC patients. A retrospective study involving 103 patients with OSCC was conducted. Disease-specific survival (DSS) according to the preoperative psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC) was evaluated. Univariate and multivariate analyses were performed to determine the predictive performance of the covariates with respect to DSS. The DSS rate in patients with high IMAC and low PMI was significantly lower than in controls. Multivariate analysis revealed that a low preoperative Prognostic Nutritional Index (PNI) and high IMAC were independent risk factors. We demonstrated that preoperative malnutrition and abnormal body composition, such as preoperative skeletal muscle quality, are associated with DSS in OSCC patients. Our study suggests that the evaluation of preoperative malnutrition and skeletal muscle quality would be useful for predicting mortality in patients with OSCC.</p>

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