Prognostic Factors and Prediction of Survival for Patients with Brain Metastases of Lung Adenocarcinoma
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- Zheng Rongjiong
- Department of Pulmonology, Ningbo Yinzhou No 2. Hospital
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- Guo Dina
- Department of Pulmonology, Ningbo Yinzhou No 2. Hospital
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- Dong Yongquan
- Department of Pulmonology, Ningbo Yinzhou No 2. Hospital
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- Wang Mingming
- Department of Pulmonology, Ningbo Yinzhou No 2. Hospital
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- Hu Meiling
- Cixi People's Hospital of Zhejiang Province
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- Ren Yifeng
- Department of Pulmonology, Ningbo Yinzhou No 2. Hospital
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説明
<p>Background: The study aimed to identify risk factors associated with overall survival (OS) of patients with lung adenocarcinoma (LACA) with brain metastasis and developed a prognostic tool (nomogram) for these patients. Methods: LACA patients with brain metastases between 2010 and 2013 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier analysis and a Cox regression model were used to assess the prognostic effect of variables on survival rate. A nomogram was developed to predict 3-, 6- and 9-month OS rates. Results: 2,631 LACA patients with brain metastases were studied. A nomogram was developed by using variables that affected OS and was validated by internal bootstrap resampling, which revealed that the nomogram had satisfactory discrimination. Conclusions: The nomogram was able to predict 3-, 6- and 9-month OS for patients with LACA and brain metastases.</p>
収録刊行物
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- 日医大誌
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日医大誌 88 (4), 319-325, 2021-08-25
日本医科大学医学会