Clinical Utility of Plasma NT-proANP Measurement Using ELISA in Dogs with Mitral Valve Disease
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- HORI Yasutomo
- School of Veterinary Medicine, Rakuno Gakuen University Otsuka-ekimae Animal Hospital Cardiovascular Medical Clinic
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- ISAYAMA Noriko
- Uenonomori Animal Clinic
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- HARAGUCHI Junko
- Kalen animal clinic
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- YAMASHITA Yohei
- Ebisu Animal Hospital
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- SAKAKIBARA Keiichiro
- North Animal Clinic
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- HEISHIMA Yasuhiro
- Heisei Animal Hospital
Bibliographic Information
- Other Title
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- 僧帽弁閉鎖不全症犬におけるELISA法を用いたNT-proANP測定法の臨床的意義
- ソウボウベン ヘイサ フゼンショウケン ニ オケル ELISAホウ オ モチイタ NT-proANP ソクテイホウ ノ リンショウテキ イギ
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Abstract
<p>Cardiac biomarkers are elevated in dogs with heart diseases including mitral valve disease (MVD). However, the difference in the regulation of atrial natriuretic peptide (ANP), N-terminal proANP (NT-proANP), N-terminal proB-type natriuretic peptide (NT-proBNP), and cardiac troponin-I (cTnI) in dogs with MVD has not been studied. We investigated plasma NT-proANP levels by MVD severity, and compared their clinical utility for assessing MVD severity. Clinically healthy dogs and client-owned dogs with MVD were examined. The diseased dogs were divided into three groups based on the American College of Veterinary Internal Medicine guidelines. Concentrations of plasma ANP, NT-proANP, NT-proBNP, and cTnI were analyzed by a commercial laboratory. Plasma ANP and NT-proANP concentrations increased significantly in stage B2 and C compared with that in the controls. They also increased significantly in stage C compared with that in stage B1. Plasma NT-proBNP and cTnI concentrations increased significantly in stage C compared with that in the controls and stage B1. Plasma NT-proANP concentration showed a strong positive correlation with ANP and NT-proBNP, and a weak positive correlation with E wave velocity, left atrial-to-aortic diameter ratio (LA/Ao raito), the left ventricular end-diastolic internal diameter corrected for body weight (LVIDDN), and VHS. The areas under the receiver-operating characteristic curve of NT-proANP used to identify dogs with each stage of MVD were comparable for other biomarkers. Circulating NT-proANP increase from the early stages of MVD, and it may be useful for assessing asymptomatic MVD. It can support echocardiographic data, but cannot be used alone to diagnose MVD.</p>
Journal
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- Advances in Animal Cardiology
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Advances in Animal Cardiology 54 (1), 15-25, 2021
Japanese Society of Veterinary Cardiology
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Details 詳細情報について
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- CRID
- 1390570930251395328
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- NII Article ID
- 130008089746
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- NII Book ID
- AN10192925
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- ISSN
- 18835260
- 09106537
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- NDL BIB ID
- 031775442
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed