Characterization of the Structural Diversity and Structure-Specific Behavior of Oxidized Phospholipids by LC-MS/MS

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  • Aoyagi Ryohei
    Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS)
  • Yamamoto Takahiro
    Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS)
  • Furukawa Yuuki
    Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS)
  • Arita Makoto
    Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS) Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama-City University

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<p>Polyunsaturated fatty acids (PUFAs), esterified to phospholipids, are susceptible to oxidation. They form oxidized phospholipids (OxPLs) by oxygenases or reactive oxygen species (ROS), or both. These OxPLs are associated with various diseases, such as atherosclerosis, pulmonary injuries, neurodegenerative diseases, cancer, and diabetes. Since many types of OxPLs seem to be generated in vivo, precise determination of their structural diversity is required to understand their potential structure-specific functions. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful method to quantitatively measure the structural diversity of OxPLs present in biological samples. This review outlines recent advances in analytical methods for OxPLs and their physiological relevance in health and diseases.</p>

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