Study on the relationship between ultrasound exposure time and cellular drug uptake in DDS
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- Kajie Kano
- Tokyo Institute of Technology
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- Peng Zugui
- Tokyo Institute of Technology
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- Yamamoto Yogo
- Tokyo Institute of Technology
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- Shimba Kenta
- The university of Tokyo
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- Miyamoto Yoshitaka
- Natural Center for Child Health and Development
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- Yagi Tohru
- Tokyo Institute of Technology
Bibliographic Information
- Other Title
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- DDSにおける超音波照射時間と細胞薬物取込の関係に関する研究
Abstract
<p>In the ultrasound-assisted drug delivery system (DDS), the target cells are irradiated with ultrasound waves to temporarily puncture the cell membrane, and at the same time, the drug is released from the nano-size liposomes which have the same structure as cell membrane and taken up by the cells. However, the relationship between drug uptake and ultrasound irradiation time has not been clarified. In this experiment, we irradiate artificial cell, which are micro-size liposomes, with ultrasound in a solution containing a fluorescent substance that we assume to be a drug. The results suggest that the uptake of the fluorescent substance increases as the irradiation time increases. In the future, we will conduct ultrasound irradiation experiments under other conditions, explore the relationship between drug uptake and each irradiation condition, and apply the results to DDS.</p>
Journal
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- Transactions of Japanese Society for Medical and Biological Engineering
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Transactions of Japanese Society for Medical and Biological Engineering Annual59 (Abstract), 571-571, 2021
Japanese Society for Medical and Biological Engineering
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Details 詳細情報について
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- CRID
- 1390571240017329664
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- NII Article ID
- 130008105495
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- ISSN
- 18814379
- 1347443X
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed