Study on the relationship between ultrasound exposure time and cellular drug uptake in DDS

DOI

Bibliographic Information

Other Title
  • DDSにおける超音波照射時間と細胞薬物取込の関係に関する研究

Abstract

<p>In the ultrasound-assisted drug delivery system (DDS), the target cells are irradiated with ultrasound waves to temporarily puncture the cell membrane, and at the same time, the drug is released from the nano-size liposomes which have the same structure as cell membrane and taken up by the cells. However, the relationship between drug uptake and ultrasound irradiation time has not been clarified. In this experiment, we irradiate artificial cell, which are micro-size liposomes, with ultrasound in a solution containing a fluorescent substance that we assume to be a drug. The results suggest that the uptake of the fluorescent substance increases as the irradiation time increases. In the future, we will conduct ultrasound irradiation experiments under other conditions, explore the relationship between drug uptake and each irradiation condition, and apply the results to DDS.</p>

Journal

Details 詳細情報について

  • CRID
    1390571240017329664
  • NII Article ID
    130008105495
  • DOI
    10.11239/jsmbe.annual59.571
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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