A strategy for rapid and easy measurement of plasma concentration of pazopanib.
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- Ogata Genki
- Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan
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- Saiki Takuro
- Department of Molecular Physiology, Niigata University School of Medicine, Niigata, Japan Department of Medical Oncology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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- Sawamura Seishiro
- Division of Glocal Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan
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- Razvina Olga
- Department of Molecular Physiology, Niigata University School of Medicine, Niigata, Japan
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- Watanabe Kota
- Department of Molecular Physiology, Niigata University School of Medicine, Niigata, Japan
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- Kato Rito
- Department of Molecular Physiology, Niigata University School of Medicine, Niigata, Japan
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- Asai Kai
- Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan
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- Hanawa Ai
- Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan
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- Matsumoto Yoshifumi
- Department of Medical Oncology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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- Moriyama Masato
- Department of Medical Oncology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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- Saijo Yasuo
- Department of Medical Oncology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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- Kusuhara Hiroyuki
- Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
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- Einaga Yasuaki
- Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan
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- Hibino Hiroshi
- Division of Glocal Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan
Bibliographic Information
- Other Title
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- 血漿パゾパニブ濃度の迅速・簡便測定を目指した計測システムの構築
Abstract
<p>Molecular-targeted anticancer drugs are administrated for any patients in a fixed-dose. The plasma concentration considerably varies among individuals, inducing serious adverse events in some occasions. Recent studies showed relevance of the plasma drug level to the efficacy and toxicity. Nevertheless, the measurement at clinical sites has not yet been fully achieved, owing to lack of the rapid and easy method. To address this issue, we developed a strategy with an electrochemical sensor composed of conductive diamond. Initially, rat plasma mixed in advance with pazopanib was tested. Linear concentration-dependent response was observed along the therapeutic window. Each measurement took ~35 s, and the process was completed in ~10 min. Next, from rats orally administered with pazopanib, and blood of < 60 μL were longitudinally sampled multiple times. Measured Tmax was ~4 hours, as described in the literature. Finally, we constructed a portable, palm-size device. These approaches accelerate tailored medicine for cancer.</p>
Journal
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- Transactions of Japanese Society for Medical and Biological Engineering
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Transactions of Japanese Society for Medical and Biological Engineering Annual59 (Abstract), 317-317, 2021
Japanese Society for Medical and Biological Engineering
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Details 詳細情報について
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- CRID
- 1390571240017854464
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- NII Article ID
- 130008105316
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- ISSN
- 18814379
- 1347443X
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed