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Evaluation of controlled release from doxorubicin-loaded nanoparticles under ultrasound irradiation
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- Shinzato Miryu
- Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan
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- Kato Yuji
- Faculty of Information Science and Technology, Hokkaido University, Sapporo, Japan
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- Hashimoto Mamoru
- Faculty of Information Science and Technology, Hokkaido University, Sapporo, Japan
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- Kudo Nobuki
- Faculty of Information Science and Technology, Hokkaido University, Sapporo, Japan
Bibliographic Information
- Other Title
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- 超音波照射下におけるドキソルビシン付着型アルブミンナノ粒子の徐放性の評価
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Description
<p>To reduce anticancer drug side effects, doxorubicin (DOX) loaded albumin nanoparticles (DOX-Alb) that can realize targeting function to cancerous tissues and controlled DOX release by ultrasound irradiation were developed. Although DOX dynamics in the cytoplasm can be visualized by fluorescence microscopy, it is difficult to quantify the amount of DOX in the nucleus because DOX fluorescence is quenched when it intercalates with nucleic acids. A method has been proposed to evaluate DOX concentration in the nucleus by staining with Hoechst 33342 that also intercalates with nucleic acids. In this study, we applied the method to investigate the possibility of controlling DOX release by ultrasound irradiation. Experimental results indicated that cytoplasmic Dox fluorescence is higher in cells cultured with Dox-Alb and that nucleic Hoechst fluorescence is lower in cells cultured with a higher Dox concentration medium, whereas cells cultured in DOX-Alb (US+, US-) culture mediums showed the different trends.</p>
Journal
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- Transactions of Japanese Society for Medical and Biological Engineering
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Transactions of Japanese Society for Medical and Biological Engineering Annual59 (Abstract), 322-322, 2021
Japanese Society for Medical and Biological Engineering
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Details 詳細情報について
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- CRID
- 1390571240018100736
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- NII Article ID
- 130008105239
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- ISSN
- 18814379
- 1347443X
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed