Intake of Docosahexaenoic Acid-Enriched Milk Beverage Prevents Age-Related Cognitive Decline and Decreases Serum Bone Resorption Marker Levels

DOI Web Site Web Site PubMed 3 Citations 44 References
  • Ichinose Takashi
    Research Institute for Creating the Future, Fuji Oil Holdings Inc.
  • Matsuzaki Kentaro
    Department of Environmental Physiology, Shimane University Faculty of Medicine
  • Kato Masaharu
    R&D Division, Fuji Oil Co., Ltd.
  • Tanabe Yoko
    Department of Environmental Physiology, Shimane University Faculty of Medicine
  • Tachibana Nobuhiko
    Research Institute for Creating the Future, Fuji Oil Holdings Inc.
  • Morikawa Miwako
    R&D Division, Fuji Oil Co., Ltd.
  • Kato Setsushi
    Kato Hospital, Jinjukai Healthcare Corporation
  • Ohata Shuzo
    Kato Hospital, Jinjukai Healthcare Corporation
  • Ohno Miho
    Kato Hospital, Jinjukai Healthcare Corporation
  • Wakatsuki Harumi
    Department of Environmental Physiology, Shimane University Faculty of Medicine
  • Hossain Shahdat
    Department of Environmental Physiology, Shimane University Faculty of Medicine Department of Biochemistry and Molecular Biology, Jahangirnagar University
  • Shido Osamu
    Department of Environmental Physiology, Shimane University Faculty of Medicine
  • Hashimoto Michio
    Department of Environmental Physiology, Shimane University Faculty of Medicine

Search this article

Description

<p>The pathogenic mechanism of dementia is still unknown, and the fundamental treatment remains to be established. Thus, there is growing interest in preventing dementia through diet. One of the functional ingredients attracting attention is docosahexaenoic acid. We conducted a 12-month, randomized, double-blind, placebo-controlled clinical trial in healthy elderly Japanese individuals with a Mini-Mental State Examination score of 28 or higher at baseline using a docosahexaenoic acid-enriched milk beverage containing 297 mg docosahexaenoic acid and 137 mg eicosapentaenoic acid. Consumption of a docosahexaenoic acid-enriched milk beverage increased the fatty acid levels of docosahexaenoic acid and eicosapentaenoic acid in erythrocyte membranes, which was the primary outcome of this study. Moreover, intake of this beverage prevented age-related cognitive decline and decreased serum bone resorption marker levels. Our data demonstrate that, even at a low dose, long-term daily intake of docosahexaenoic acid prevents dementia and may show beneficial effect on bone health.</p>

Journal

Citations (3)*help

See more

References(44)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top