A feasibility study on cervical screening in non-attenders invited to undergo HPV self-sampling with cytology triage versus repeat invitation for cytology screening in Hokkaido

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  • TANIGUCHI Shinobu
    Ebetsu City Public Health Promotion Office Health and Welfare Department
  • SAKURAGI Noriaki
    Otaru General Hospital Women's Healthcare Center Hokkaido University General Incorporated Association PCAF
  • HANLEY Sharon J. B.
    Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine General Incorporated Association PCAF
  • TSUKIYAMA Kizuna
    Ebetsu City Public Health Promotion Office Health and Welfare Department
  • FUJITA Hiromasa
    Cytology Center, Public Interest Foundation Hokkaido Cancer Society General Incorporated Association PCAF
  • SAGAE Satoru
    Hokkaido Ohno Memorial Hospital Gynecologic Cancer Center General Incorporated Association PCAF
  • KAJII Naofumi
    Ebetsu City Public Health Promotion Office Health and Welfare Department
  • WATARI Hidemichi
    Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine
  • TAMAKOSHI Akiko
    Department of Public Health, Hokkaido University Graduate School of Medicine

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Other Title
  • 細胞診と自己採取ヒトパピローマウイルス検査を選べることの効果：北海道での子宮頸がん検診未受診者対策の成績
  • サイボウシン ト ジコ サイシュ ヒトパピローマウイルス ケンサ オ エラベル コト ノ コウカ : ホッカイドウ デ ノ シキュウケイガン ケンシン ミジュシンシャ タイサク ノ セイセキ

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<p>Objectives　We investigated the participation and detection rates of cervical lesions in cervical screening non-attenders offered HPV (human papillomavirus) self-sampling with cytology triage.</p><p>Methods　From 2016 to 2018, HPV self-sampling was routinely offered as an option, along with cytology, to all non-attenders in Ebetsu City, Japan. The primary endpoints were ≥CIN2 and ≥CIN3 detection rates, and secondary endpoints were abnormal cytology rates and follow-up compliance.</p><p>Results　Overall, recall invitations were mailed to 6,116 non-attenders, with a response rate of 15.9% (cytology: 6.5%, HPV testing: 9.4%). Of the responders to undergo HPV self-sampling, 11.7% had a positive result and were referred to cytology triage. Moreover, ≥CIN2 and ≥CIN3 detection rates were 1.7% and 0.9%, respectively, in the HPV self-sampling group, and 1.0% and 0.8%, respectively, in the cytology group, showing no statistically significant differences. In those who underwent cytology triage following an HPV positive test, ≥CIN2 and ≥CIN3 detection rates were 23.8% and 11.9%, respectively, which was significantly higher than those who only underwent cytology alone.</p><p>Conclusion　HPV self-sampling followed by cytology triage is highly effective at detecting high grade disease in non-attenders. Thus, multi-municipality-based studies to standardize processes involving this method are warranted. Furthermore, HPV self-sampling could be a promising method for inviting non-attenders who have difficulty undergoing cervical screening in the COVID-19 pandemic era.</p>

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