Activation mechanism of zinc-requiring ectoenzymes: A consideration from zinc nutrition

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  • Ueda Sachiko
    Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University
  • Kambe Taiho
    Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University

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  • エクト型亜鉛要求性酵素の活性化機構：亜鉛栄養を絡めた考察
  • エクトガタ アエン ヨウキュウセイ コウソ ノ カッセイカ キコウ : アエン エイヨウ オ カラメタ コウサツ

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Abstract

<p>Recently, zinc ectoenzymes have received much attention owing to their important physiological and pathophysiological roles. They are thought to be activated through coordination with zinc, which is supplied by zinc transporters, ZNTs, which play a role in the early secretory pathway. However, the molecular mechanisms underlying the activation remain largely unknown. With an emphasis on recent findings, this manuscript briefly discusses an array of topics related to zinc ectoenzyme activation by the zinc transporters, specifically ZNT5-ZNT6 heterodimers and ZNT7 homodimers. Moreover, zinc ectoenzyme activation has been studied considering zinc deficiency, which reveals the importance of zinc in nutrition for the maintenance of good health.</p>

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