Histological Distribution of MHC Class II‒expressing Cells Responsible for Ingestion of Blood‒borne Exogenous Particles in Japanese Flounder <i>Paralichthys olivaceus</i>

  • Kurata Osamu
    Laboratory of Aquatic Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University
  • Miyashita Suyu
    Laboratory of Aquatic Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University
  • Wada Shinpei
    Laboratory of Aquatic Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University

Bibliographic Information

Other Title
  • 血液中の異物を捕食するヒラメMHCクラスII発現細胞の組織分布
  • Histological Distribution of MHC Class Ⅱ : expressing Cells Responsible for Ingestion of Blood-borne Exogenous Particles in Japanese Flounder Paralichthys olivaceus

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Description

<p>This study investigated the ability of MHC class II‒expressing cells to ingest blood-borne exogenous particles and their tissue distribution in Japanese flounder Paralichthys olivaceus. ​Carbon particles were injected into a blood vessel in the caudal peduncle. ​After 3 h, carbon-laden MHC class II‒expressing cells were found in the spleen and the kidney, and localised in ellipsoids, splenic cords, peritubular sinuses and interstitial veins of the kidney. ​Additionally, the percentage of these cells was significantly higher in the spleen than the kidney. ​These results suggest that the spleen is the main organ that plays a role in the ingestion of blood‒borne exogenous particles for antigen presentation.</p>

Journal

  • Fish Pathology

    Fish Pathology 56 (4), 216-219, 2021-12-15

    The Japanese Society of Fish Pathology

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