The frequencies of knockdown resistance mutations in phlebotomine sandflies under different degrees of indoor residual spraying
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- Kuroki Akihiro
- Laboratory of Molecular Immunology, Graduate School of Agricultural and Life Sciences, University of Tokyo
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- Itokawa Kentaro
- Pathogen Genomics Center, National Institute of Infectious Diseases
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- Özbel Yusuf
- Department of Parasitology, Ege University Faculty of Medicine
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- Komagata Osamu
- Department of Medical Entomology, National Institute of Infectious Diseases
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- Osada Yasutaka
- Laboratory of Molecular Immunology, Graduate School of Agricultural and Life Sciences, University of Tokyo
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- Omachi Satoko
- Laboratory of Molecular Immunology, Graduate School of Agricultural and Life Sciences, University of Tokyo
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- Sarkar Santana Rani
- Department of Microbiology, Mymensingh Medical College
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- Rahman Fashiur
- Department of Microbiology, Mymensingh Medical College
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- Paul Shyamal Kumar
- Department of Microbiology, Mymensingh Medical College
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- Kasai Shinji
- Department of Medical Entomology, National Institute of Infectious Diseases
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- Sawabe Kyoko
- Department of Medical Entomology, National Institute of Infectious Diseases
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- Matsumoto Yoshitsugu
- Laboratory of Molecular Immunology, Graduate School of Agricultural and Life Sciences, University of Tokyo
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- Noiri Eisei
- Hemodialysis and Apheresis, Nephrology 107 Lab, The University of Tokyo Hospital
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- Sanjoba Chizu
- Laboratory of Molecular Immunology, Graduate School of Agricultural and Life Sciences, University of Tokyo
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説明
<p>The emergence of pyrethroid resistance in Phlebotomus sandflies is an urgent issue for vector control using indoor residual spraying (IRS). Two amino acid substitutions at codon 1014 (L1014F and L1014S) in the voltage-gated sodium channel (VGSC) gene have been reported in Phlebotomus argentipes, a major vector of visceral leishmaniasis (VL). Known as “knockdown resistance (kdr),” these substitutions confer pyrethroid resistance in various insect species. The frequency of the VGSC mutant allele was investigated in Phlebotomus and Sergentomyia species at two different IRS regimes: “long-term treated,” 12 rounds for seven years in Mymensingh, Bangladesh; “short-term treated,” four rounds for two years in Pabna, Bangladesh. In Mymensingh, the L1014F/S allele frequency was 100% in P. argentipes and 98% in S. babu babu. In Pabna, the frequency was 41% in P. argentipes. At other kdr sites (codons 1011, 1016, and 1020), the genotypes of all specimens in Bangladesh were wild-type homozygotes. This study showed that a long and frequent exposure to IRS is crucial for the development of genetic mutations in VGSCs, a higher kdr frequency, and pyrethroid resistance in Phlebotomus.</p>
収録刊行物
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- 衛生動物
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衛生動物 72 (4), 229-236, 2021-12-25
日本衛生動物学会
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詳細情報 詳細情報について
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- CRID
- 1390572012410190976
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- NII論文ID
- 130008134506
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- NII書誌ID
- AN00021948
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- ISSN
- 21855609
- 04247086
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- NDL書誌ID
- 031873285
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可