Ophthalmic background findings of Göttingen minipigs
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- YAMAMOTO Tetsuya
- Tsukuba Research Institute, BoZo Research Center Inc.
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- OGAWA Tatsuya
- Tsukuba Research Institute, BoZo Research Center Inc.
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- KATO Shuhei
- Tsukuba Research Institute, BoZo Research Center Inc.
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- NAGI Osamu
- Tsukuba Research Institute, BoZo Research Center Inc.
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- FUKUNAGA Yachiyo
- Tsukuba Research Institute, BoZo Research Center Inc.
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- MOCHIZUKI Masahiro
- Tsukuba Research Institute, BoZo Research Center Inc.
Bibliographic Information
- Other Title
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- ゲッチンゲンミニブタの眼科的背景所見
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Abstract
<p>Göttingen minipigs of 12 males and 12 females were kept from 3- to 14-month old, and subjected to periodical examination of the eye to investigate ophthalmological background. Ununiform pigmentation of the iris was found by visual examination, and persistent pupillary membrane, persistent hyaloid artery, persistent tunica vasculosa lentis and tigroid fundus by the indirect ophthalmoscope and slit lamp biomicroscope. These findings were considered congenital. Lens opacity was noted in various forms at various regions of the lens. The lens opacity of the granular form was already present in the anterior cortex at 3-month old, and remained unchanged for the incidence and degree up until 14-month old, whereas the incidences of the opacity located in the nucleus, posterior cortex and posterior capsule appeared to increase with age of animals. Of note, the focal form of opacity localized in the posterior cortex, and granular, focal and diffuse forms of opacity in the posterior capsule became evident beyond 9-month old. From these findings, the onset of spontaneous lens opacity was carefully taken into account when evaluating toxicity studies using Göttingen minipigs.</p>
Journal
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- Animal Eye Research
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Animal Eye Research 39 (0), 9-13, 2020-12-25
Japanese Society of Comparative and Veterinary Ophthalmology
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Keywords
Details 詳細情報について
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- CRID
- 1390572034439996544
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- NII Article ID
- 130008138216
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- ISSN
- 21858446
- 02867486
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed