Inhibitory Action of Mibefradil on T-Type Calcium Channels in Early Embryonic Mouse Ventricular Myocytes
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説明
Mibefradil has been reported to preferentially block T-type Ca^<2+> channel currents in many different tissues including heart with variable potencies. We recorded T-type Ca^<2+> currents (I_<Ca-T>) in early embryonic (9.5 day post coitum (dpc)) mouse ventricular myocytes using a whole-cell patch clamp method and studied the effects of mibefradil. ICa T were inhibited by mibefradil in a concentration- dependent manner with half inhibitory concentration (IC_<50>) at 3.4 ± 0.2 μM. This value is higher than those reported for native adult and neonatal atrial myocytes (0.1-1.5 μM). Factors affecting the mibefradil sensitivity of I_<Ca-T>, in particular different subtypes of α1 subunits, are discussed.
収録刊行物
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- Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University
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Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 46 (1/2), 84-85, 2002-12
Research Institute of Environmental Medicine, Nagoya University
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詳細情報 詳細情報について
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- CRID
- 1390572174357586432
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- NII論文ID
- 110000029092
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- NII書誌ID
- AA1051621X
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- HANDLE
- 2237/2792
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- ISSN
- 02870517
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- 本文言語コード
- en
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- JaLC
- IRDB
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用可