Inhibitory Action of Mibefradil on T-Type Calcium Channels in Early Embryonic Mouse Ventricular Myocytes

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説明

Mibefradil has been reported to preferentially block T-type Ca^<2+> channel currents in many different tissues including heart with variable potencies. We recorded T-type Ca^<2+> currents (I_<Ca-T>) in early embryonic (9.5 day post coitum (dpc)) mouse ventricular myocytes using a whole-cell patch clamp method and studied the effects of mibefradil. ICa T were inhibited by mibefradil in a concentration- dependent manner with half inhibitory concentration (IC_<50>) at 3.4 ± 0.2 μM. This value is higher than those reported for native adult and neonatal atrial myocytes (0.1-1.5 μM). Factors affecting the mibefradil sensitivity of I_<Ca-T>, in particular different subtypes of α1 subunits, are discussed.

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