Relationships between Concentrations of Dioxin Isomers and Symptoms, and among Concentrations and Half-Lives of Dioxin Isomers, in Patients with Yusho Disease

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  • Matsumoto Shinya
    Division of Social Medicine, Graduate School of Medicine, The University of Tokyo | Department of Public Health, Health Management and Policy, Nara Medical University School of Medicine
  • Akahane Manabu
    Department of Public Health, Health Management and Policy, Nara Medical University School of Medicine
  • Kanagawa Yoshiyuki
    Division of Social Medicine, Graduate School of Medicine, The University of Tokyo
  • Kajiwara Jumboku
    Fukuoka Institute of Health and Environmental Sciences
  • Uchi Hiroshi
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University | Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital
  • Furue Masutaka
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University | Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital
  • Imamura Tomoaki
    Department of Public Health, Health Management and Policy, Nara Medical University School of Medicine

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Other Title
  • 油症患者におけるダイオキシン類異性体ごとの症状ならびに異性体間の濃度と半減期の関係
  • ユショウ カンジャ ニ オケル ダイオキシンルイ イセイタイ ゴト ノ ショウジョウ ナラビニ イセイタイ カン ノ ノウド ト ハンゲンキ ノ カンケイ

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Abstract

The relationships among dioxin isomers are not well understood. This study aimed to clarify the relationships among isomers using two methods. First, the relationships between isomers and symptoms were analyzed by analysis of variance. Second, concentrations and half-lives were determined for each isomer in each patient, and correlation coefficients for the concentrations and half-lives among isomers were calculated. Two isomers very similar to 2, 3, 4, 7, 8-pentachlorodibenzofuran (2, 3, 4, 7, 8-PeCDF) were correlated with symptoms of Yusho disease. The correlation coefficients among three isomers similar to 2, 3, 4, 7, 8-PeCDF were very high at 0.98, indicating that there may be a mechanism which maintains constant ratios among these isomers.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 104 (4), 78-84, 2013-04-25

    Fukuoka Medical Association

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