Immunohistological Localization of Peroxisome Proliferator-Activated Receptor α and γ in Human Sebaceous Glands

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  • Furue Masutake
    Department of Dermatology, Kyushu University | Division of Skin Surface Sensing, Department of Dermatology, Kyushu University | Research and Clinical Center for Yusho and Dioxin, Kyushu University
  • Takemura Masaki
    Department of Dermatology, Kyushu University
  • Nishio Kiichiro
    Department of Dermatology, Kyushu University
  • Sato Yuki
    Department of Dermatology, Kyushu University
  • Nagata Shoko
    Department of Dermatology, Kyushu University
  • Kan Nagisa
    Department of Dermatology, Kyushu University
  • Suenaga Asako
    Department of Dermatology, Kyushu University
  • Furue Kazuhisa
    Department of Dermatology, Kyushu University
  • Yoshida Maiko
    Department of Dermatology, Kyushu University
  • Konishi Sawako
    Department of Dermatology, Kyushu University
  • Tsuji Gaku
    Department of Dermatology, Kyushu University | Research and Clinical Center for Yusho and Dioxin, Kyushu University

Bibliographic Information

Other Title
  • ヒト脂腺におけるPeroxisome Proliferator-Activated Receptor α(PPARα) とPPARγの免疫組織学的発現

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Abstract

The immunohistological localization of peroxisome proliferator-activated receptorα(PPARα) and PPARγ was examined in 28 pilosebaceous units in 10 paraffin-embedded normal human skin specimens. Rabbit polyclonal antibody against human PPARαand monoclonal antibody against human PPARγwere used as specific primary antibodies. The nuclear and cytoplasmic expression of PPARαwas detected in basal to differentiated sebocytes. In contrast, the expression of PPARγwas confined to nuclei of suprabasal to early-differentiated sebocytes. The nuclear PPARγexpression was present only occasionally in the basal sebocytes. These results suggest that PPARαand PPARγare integral parts of sebocyte differentiation in human sebaceous glands.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 107 (11), 199-203, 2016-11-25

    Fukuoka Medical Association

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