油症における塩素痤瘡と色素沈着の発症機序とその対策 : aryl hydrocarbon receptorの役割

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  • 古江 増隆
    九州大学病院油症ダイオキシン研究診療センター 九州大学大学院医学研究院皮膚科学分野

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タイトル別名
  • Pathogenesis of Chloracne and Hyperpigmentation in Yusho : Role of Aryl Hydrocarbon Receptor
  • ユショウ ニ オケル エンソザソウ ト シキソ チンチャク ノ ハッショウ キジョ ト ソノ タイサク : aryl hydrocarbon receptor ノ ヤクワリ

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抄録

Yusho, occurred in 1968, is an intoxication of high concentrations of polychlorinated dibenzofurans and their related compounds. Like other intoxication by dioxin-like compounds, one of the major symptoms of Yusho is skin symptom such as chloracne and pigmentation. Dioxins exert their major toxicity by binding and activating aryl hydrocarbon receptor (AHR) and subsequent generation of reactive oxygen species (ROS). Sustained and exaggerated AHR activation by dioxins accelerates the keratinization of keratinocytes and converts the sebaceous differentiation of sebocytes to keratinocyte-like differentiation which results in loss of sebocytes and cyst formation of hair follicle, leading to chloracne. AHR activation by dioxins upregulates the melanogenesis of melanocytes, leading to pigmentation. Phytochemical Kampo drugs which inhibit AHR activation and subsequent ROS production are potential treatment for Yusho patients.

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