書誌事項
- タイトル別名
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- Research on the Mitochondrial Zone Responsible for Innate Immunity
- コウウイルス シゼン メンエキ ニ オケル ミトコンドリア ノ オウトウ ゾーン
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抄録
A multi-functional organelle, mitochondrion, participates in a wide variety of cellular processes from energy metabolism to cell death. Current researches on mitochondria in mammals revealed that they involve in the cellular innate immune response against infectious microorganisms or sterile activators. The mitochondrion-related innate immune response is accomplished by the activation of two distinct signaling transduction pathways, that are the retinoic acid-inducible gene I (RIG-I) pathway and the NLR family pyrin domain-containing 3 (NLRP3) inflammasomes. In both signaling pathways, a mitochondrial outer membrane adaptor protein, mitochondrial antiviral signaling (MAVS), acts as a key role in the signal transduction. In this review, we take a view of our current insights regarding the fundamental phenomena of mitochondrion-related innate immunity, and review the specific roles of the mitochondrial zone responsible for the immune responses.
収録刊行物
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- 福岡醫學雜誌
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福岡醫學雜誌 111 (2), 77-85, 2020-06-25
福岡医学会
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詳細情報 詳細情報について
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- CRID
- 1390572174718240512
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- NII論文ID
- 120006890296
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- NII書誌ID
- AN00215478
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- DOI
- 10.15017/4068637
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- HANDLE
- 2324/4068637
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- NDL書誌ID
- 030715237
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- ISSN
- 0016254X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- IRDB
- NDL
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用可