書誌事項
- タイトル別名
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- Half-Lives of Dioxin-Like-Compounds in Blood are Prolonged in Yusho Patients
- カネミユショウ ニ オケル ダイオキシンルイ ノ ハイシュツ ソクド ワ エンチョウ シテ イル
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抄録
Yusho, the mass food poisoning, occurred in western Japan in 1968. PCBs and dioxin like compounds such as 2,3,4,7,8-PeCDF were detected as causal chemicals for Yusho. Our group have measured blood concentrations of dioxin-like compounds and analyzed their half-lives. In our previous studies, we have found two groups ; one group has 7-10 years of half-lives as reported by other researchers, and the other group has near infinite half-lives. In addition, the number of patients in group showing 7-10 years of half-lives decreased and the number in group with near infinite half-lives increased. However, those changes were not evaluated in individual patient since follow-up period was relatively short to analyze the individual half-live. Therefore, we now intend to evaluate the long-term change of half-life in individual patient. Our preliminary analysis indicates that the half-life of 2,3,4,7,8-PeCDF appears to be prolonged in each patient. Considering the recent low levels of environmental contamination of dioxins and their related compounds, the prolonged half-life of blood concentration of 2,3,4,7,8-PeCDF points its deteriorated excretion.
収録刊行物
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- 福岡醫學雜誌
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福岡醫學雜誌 110 (2), 67-72, 2019-06-25
福岡医学会
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詳細情報 詳細情報について
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- CRID
- 1390572174718337536
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- NII論文ID
- 120006707656
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- NII書誌ID
- AN00215478
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- DOI
- 10.15017/2328857
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- HANDLE
- 2324/2328857
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- NDL書誌ID
- 029881122
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- ISSN
- 0016254X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用可