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- Yoshikai Yasunobu
- Division of Host Defense, Medical Institute of Bioregulation, Kyushu University
Bibliographic Information
- Other Title
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- 生体防御は個体発生を繰り返す : γδ型T細胞と感染防御
- セイタイ ボウギョ ワ コタイ ハッセイ オ クリカエス : gdガタ Tサイボウ ト カンセン ボウギョ
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Abstract
In the thymus, two types of T cells develop : γδ T cell receptor (TCR)-positive cells, which develop from the CD4^-CD8^- double-negative (DN) stage, whereas cell populations that enter the CD4^+CD8^+ double-positive (DP) stage become αβ T cells. Unlike conventional αβ T cells, which are exported from the thymus as naïve cells and acquire effector functions upon encountering antigen in the periphery, γδ T cells are functionally committed to forming effector cells that produce inflammatory cytokines such as interferon (IFN)-g and interleukin (IL)-17 and mount cytotoxic responses upon activation within the thymus and are disproportionately distributed within mucosal epithelia such as reproductive tracks, intestine and skin. These features allow γδ T cells to respond to antigens quickly without clonal expansion and function as the first line of host defense against microbial infection. Thereby I call the γδ T cells “primitive T cells”. I propose, a hypothesis “hose defense recapitulates ontogeny” on the basis of research on the γδ T cells as primitive T cells and challenge the conventional immunological paradigm to be sub-classified into innate and adaptive immunity.
Journal
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- 福岡醫學雜誌
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福岡醫學雜誌 108 (10/11), 230-236, 2017-11-25
Fukuoka Medical Association
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Details 詳細情報について
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- CRID
- 1390572174718406528
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- NII Article ID
- 120006470934
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- NII Book ID
- AN00215478
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- DOI
- 10.15017/1929750
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- HANDLE
- 2324/1929750
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- NDL BIB ID
- 029058709
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- ISSN
- 0016254X
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- Abstract License Flag
- Allowed