MTA セメントと納豆菌混和材料の齲蝕治療応用と相乗効果： 基礎的実験の意義と今後

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  • Synergistic effect of MTA cement and Bacillus subtilis admixture for caries treatment: significance of previous experiments and future developments

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Bacillus subtilis produces a number of useful substances and is nonpathogenic in humans; therefore, this bacterium is used in probiotic therapy. Indirect pulp capping with a mixture of B. subtilis spore powder and mineral trioxide aggregate (MTA) cement is effective for avoiding pulpectomy or tooth extraction (personal communication). Based on reports of the clinical utility of this mixture, we conducted a study to establish the scientific basic of this effect. A paper describing this work(Oka, 2018) included two major results: (1) B. subtilis can proliferate in an admixture with MTA cement, which has an extremely high pH, at which it was thought that neutral bacteria such as B. subtilis cannot survive; and (2) the admixture has synergistic effects with respect to antimicrobial activities. These results support the hypothesis that a combination of B. subtilis and MTA cement is likely to be clinically useful for treatment of dental caries. However, we did not fully describe the background and significance of the experiments in the previous paper(Oka, 2018). Here, we describe the details of the experiments, including presentation of unpublished data, and add a discussion of further development of this research.

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