骨粗鬆症の疼痛発生メカニズム

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  • 学内研究紹介 骨粗鬆症の疼痛発生メカニズム
  • ガク ナイ ケンキュウ ショウカイ コツソショウショウ ノ トウツウ ハッセイ メカニズム

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The nerve fibers extensively innervate bone. In addition to nerve fibers, several receptors and released many kinds of neuropeptides were identified in the bone. On the other hand, most of roles concerning receptors and neuropeptides in bone were still unknown. Recently, bone pain of musculoskeletal disease is recognized to be related pathological condition at increasing bone resorption. It is thought to be a mechanism that a highly acidic condition at a bone compartment due to proton released from activated osteoclast stimulated acid sensing receptor, and afferent signal induced bone pain. We evaluated the skeletal pain in ovariectomy (OVX) mice, which was known as a model postmenopausal osteoporosis using the examination for pain-like behavior and immunohistochemistry technique. Those pain-like behavior was assessed. The OVX mice showed a decrease in threshold value of pain, and the number of c-Fos immunoreactive neurons in the dorsal horn of the spinal cord increased in OVX mice. In addition, the effects of bisphosphonate which is the potent inhibitor of osteoclasts, improved a decrease in threshold value of pain and c-Fos expression. These results indicated that the acidic microenviroment created by bone-resorbing osteoclast could cause the skeletal pain associated with postmenopausal osteoporosis.

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