Novel Elongated Phosphoranes by Heck-Reaction and Pd(0)-Catalysed Alkynylation and their Use in C-7 Group Functionalisation in Estrones
-
- Thiemann Thies
- Institute of Advanced Material Study Kyushu University
-
- Umeno Kuniharu
- Graduate School of Engineering Sciences Kyushu University
-
- Inohae Eiko
- Graduate School of Engineering Sciences Kyushu University
-
- Mataka Shuntaro
- Institute of Advanced Material Study Kyushu University
Search this article
Abstract
Halobenzoylmethylidenephosphoranes 3 are reacted under C-C bond formation to give a number of novel elongated phosphoranes 5 and 6. The C-C bond formation could be achieved both under Heck conditions and by metal-catalyzed ethynylation reaction. The products, desactivated phosphoranes, can be reacted in Wittig-olefinations with aldehydes. Exemplary use of the phosphoranes is shown in the C-7 chain functionalisation in synthetic estrones, which may be valuable precursors for radioligands in early breast cancer diagnosis.
Journal
-
- 九州大学機能物質科学研究所報告
-
九州大学機能物質科学研究所報告 14 (1), 17-29, 2000-07-01
Institute of Advanced Material Study Kyushu University
- Tweet
Details 詳細情報について
-
- CRID
- 1390572174788966400
-
- NII Article ID
- 110006177566
-
- NII Book ID
- AN10060378
-
- ISSN
- 09143793
-
- DOI
- 10.15017/7917
-
- HANDLE
- 2324/7917
-
- NDL BIB ID
- 5466537
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- IRDB
- NDL
- CiNii Articles
-
- Abstract License Flag
- Allowed