Effects of Tadalafil 5 mg Once-Daily on Serum Testosterone Level, Erectile Function, and Highly Sensitive C-Reactive Protein Value in Hypogonadal Patients with Lower Urinary Tract Symptoms

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  • Shigehara Kazuyoshi
    The Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
  • Shimamura Masayoshi
    The Department of Urology, Nomi City Hospital
  • Kawaguchi Shohei
    The Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
  • Nohara Takahiro
    The Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
  • Izumi Kouji
    The Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
  • Kadono Yoshifumi
    The Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
  • Shouda Ryouchu
    The Department of Urology, Wajima City Hospital
  • Mizokami Atsushi
    The Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science

Bibliographic Information

Other Title
  • 下部尿路症状を伴う性腺機能低下症患者に対するタダラフィル5mg連日投与の付随効果 --テストステロン・性機能・高感度C-reactive proteinに対する効果--
  • 下部尿路症状を伴う性腺機能低下症患者に対するタダラフィル5mg連日投与の付随効果 : テストステロン・性機能・高感度C-reactivc proteinに対する効果
  • カブ ニョウロ ショウジョウ オ トモナウ セイセン キノウ テイカショウ カンジャ ニ タイスル タダラフィル 5mg レンジツ トウヨ ノ フズイ コウカ : テストステロン ・ セイ キノウ ・ コウカンド C-reactivc protein ニ タイスル コウカ

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Description

Five mg tadalafil was administered once-daily to 48 patients for 6 months. Their International Prostatic Symptoms Score (IPSS), Overactive Bladder Symptoms Score (OABSS), Sexual Health Inventory for Men (SHIM), post-voided residual (PVR) volume, free testosterone (FT) level, prostate-specific antigen level, and highly sensitive C-reactive protein (hsCRP) value obtained before and 6 months after the treatment were analyzed. The treatment significantly improved the IPSS, OABSS, SHIM score, and PVR volume (P<0.05), and significantly increased the mean FT level from 6.68 to 7.10 pg/ml ; P<0.05. We observed no significant changes in the hsCRP value and PSA level. However, elevated FT values were noted in 25 (52.1%) patients 6 months after the treatment (FT-increased group). Compared with the non-FT-increased group, the FT-increased group had markedly lower baseline FT value and higher prostatic volume. In both groups, IPSS and OABSS improved considerably. Moreover, the PVR volume, SHIM score, and hsCRP value markedly improved in the FT-increased group (P<0.05). Thus, 5 mg tadalafil administered oncedaily improved IPSS, OABSS, and erectile function, and increased the FT value, in hypogonadal patients with lower urinary tract symptoms. Furthermore, the hsCRP value declined considerably in patients with posttreatment elevated FT level.

Journal

  • 泌尿器科紀要

    泌尿器科紀要 66 (8), 259-264, 2020-08-31

    泌尿器科紀要刊行会

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