The role of astrocytes during repair of cerebral infarction in mdx mice

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  • 筋ジストロフィーモデル動物(mdxマウス)の脳梗塞修復機転におけるアストロサイトの役割について
  • キン ジストロフィー モデル ドウブツ mdx マウス ノ ノウコウソク シュウフク キテン ニ オケル アストロサイト ノ ヤクワリ ニ ツイテ

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Abstract

It is now well known that dystrophin isoforms (427kDa, 260kDa, 140kDa, 116kDa, 71-75kDa) are widely distributed throughout our body. In the central nervous system a considerable amount of Dp71 (71-75kDa) is found in the perivascular cytoplasm of the astrocytes. However, the function of this dystrophin is still unknown. To investigate the role of Dp71 in the brain tissue, cerebral infarction was induced in the control (wide-type) mouse and mdx mouse which is known as an animal model of human muscle dystrophy (Duchenne type), and morphological changes of the infarcted area were observed during repair of the infarction. In addition, biochemical analysis of GFAP and Dp71 was carried out in the brain of the control and mdx mouse. In our present study, there were no differences in brain morphology between mdx and control mouse as revealed in H-E stain and GFAP immunohistochemistry. However, the Dp71 were smaller in quantity in the brain of the mdx mouse than that of the control mouse. The reaction of astrocytes during repair of serebral infarction was distinctly delayed in the mdx mouse compared with that of the control mouse. These findings suggest that the astrocytes in the brain of the mdx mouse are functionally impaired including perivascular cytoplasmic processes with relation to neo-vascularization.

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