Successful Re-Administration of Nivolumab in Patient with Metastatic Renal Cell Carcinoma : A Case Report

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  • SASAGAWA Hajime
    The Department of Urology, Akita University Graduate School of Medicine
  • NUMAKURA Kazuyuki
    The Department of Urology, Akita University Graduate School of Medicine
  • NAKAMURA Gaku
    The Department of Urology, Akita University Graduate School of Medicine
  • KUKIMOTO Takashi
    The Department of Urology, Akita University Graduate School of Medicine
  • KIKUCHI Akane
    The Department of Urology, Akita University Graduate School of Medicine
  • SAGEHASHI Ryuichiro
    The Department of Urology, Akita University Graduate School of Medicine
  • YAMAMOTO Ryohei
    The Department of Urology, Akita University Graduate School of Medicine
  • KOIZUMI Atsushi
    The Department of Urology, Akita University Graduate School of Medicine
  • NARA Taketoshi
    The Department of Urology, Akita University Graduate School of Medicine
  • KANDA Sohei
    The Department of Urology, Akita University Graduate School of Medicine
  • SAITO Mitsuru
    The Department of Urology, Akita University Graduate School of Medicine
  • NARITA Shintaro
    The Department of Urology, Akita University Graduate School of Medicine
  • INOUE Takamitsu
    The Department of Renal and Urologic Surgery, International University of Health and Welfare Narita Hospital
  • SATOH Shigeru
    Center for Kidney Disease and Transplantation, Akita University Hospital
  • HABUCHI Tomonori
    The Department of Urology, Akita University Graduate School of Medicine

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Other Title
  • ニボルマブ再投与で治療効果を示した転移性腎細胞癌の1例
  • ニボルマブ サイトウヨ デ チリョウ コウカ オ シメシタ テンイセイジンサイボウガン ノ 1レイ

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Abstract

A 46-year-old woman was referred to our hospital with a left-sided renal tumor pointed out by ultrasonography at the time of a medical checkup．Computed tomography revealed a mass measuring 88×77×68 mm on the upper pole of the left kidney. She was diagnosed with cT2aN0M0 clear cell renal cell carcinoma. Laparoscopic left nephrectomy was performed uneventfully. Histopathological diagnosis was clear cell renal cell carcinoma, G2, v1, pT2. Four months after surgery, lung metastases appeared, and systemic therapy was given sequentially as follows ; sunitinib for 2 months, nivolumab for 8 months, axitinib for 17 months, and pazopanib for 2 months．However, metastases progressed, and a re-administration of nivolumab was planned. The nivolumab re-treatment resulted in a marked reduction in multiple lung metastases despite the previous failure by nivolumab treatment. There are few reports on the therapeutic effect of re-administration of nivolumab. We report a case of successful treatment by re-administration of nivolumab.

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  • 泌尿器科紀要

    泌尿器科紀要 67 (12), 525-528, 2021-12-31

    泌尿器科紀要刊行会

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