A case of neonatal sepsis treated with low-dose endotoxin adsorption therapy

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  • 新生児敗血症に対し低容量カラムを用いたエンドトキシン吸着療法を施行した経験
  • 症例報告 新生児敗血症に対し低容量カラムを用いたエンドトキシン吸着療法を施行した経験
  • ショウレイ ホウコク シンセイジ ハイケツショウ ニ タイシ テイヨウリョウ カラム オ モチイタ エンドトキシン キュウチャク リョウホウ オ シコウ シタ ケイケン

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Abstract

<p>Endotoxin adsorption therapy is used to treat severe sepsis. In recent years, adsorption columns have been developed to treat neonatal sepsis, of which polymyxin B-immobilized fiber (PMX) columns can even be used for low-birth-weight neonates. The infant was born at 36 weeks gestation, weighing 2504 g. Within 4 hours after birth, respiratory insufficiency due to Group B Streptococcus infection was observed. Blood pressure was stabilized after antibiotic and nitric oxide (NO) treatments; however, procalcitonin concentrations were high and symptoms of sepsis were observed. Blood purification therapy including PMX, was administered on the third day after birth. Improvement in respiration and circulation was observed after the introduction of blood purification therapy. As a result, the administration of NO and catecholamine preparations was gradually reduced, and blood purification therapy was discontinued after 53 hours. The infant was discharged about 2 months later. The development of low-dose PMX-01R has made it possible to implement the safe treatment of sepsis in newborns.</p>

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