Adsorption characteristics of various antibiotics onto AN69ST membranes

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  • Inano Yoshinori
    Division of Pharmacy, Eastern Chiba Medical Center
  • Kumano Ryota
    Division of Pharmacy, Eastern Chiba Medical Center
  • Shinozaki Koji
    Division of Pharmacy, Eastern Chiba Medical Center
  • Ozaki Yosuke
    Division of Pharmacy, Eastern Chiba Medical Center
  • Miura Go
    Laboratory of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Josai International University
  • Nakasa Hiromitsu
    Division of Pharmacy, Eastern Chiba Medical Center Department of General Medical Sciences, Graduate School of Medicine, Chiba University

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Other Title
  • AN69ST膜に対する各種抗菌薬の吸着特性
  • AN69STマク ニ タイスル カクシュ コウキンヤク ノ キュウチャク トクセイ

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Abstract

<p>AN69ST membrane hemofilters have a high adsorption ability for cytokines, but concerns exist regarding their adsorption and removal abilities for antibiotics to use for treatment. Therefore, we examined the effect of the adsorption of meropenem (MEPM), pazufloxacin (PZFX), cefozopran (CZOP), vancomycin (VCM), and teicoplanin (TEIC) onto AN69ST membranes via in vitro experiments. The adsorption ability was evaluated by measuring the absorbance of each antibiotic solution added to the AN69ST membranes over time. We observed that the content rates of TEIC, PZFX, and VCM decreased compared with those of the solution that was not added to the AN69ST membranes；however, the content rates of MEPM and CZOP showed no decrease. Therefore, our results suggest that TEIC, PZFX, and VCM were adsorbed and removed by the AN69ST membranes. Thus, while using AN69ST membranes, it is crucial to set the antibiotic dose for administration by considering the decrease in the blood level.</p>

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