Autograft of Demineralized Dentin Matrix Prepared Immediately after Extraction for Horizontal Bone Augmentation of the Anterior Atrophic Maxilla: A First Case of Non-Vital Tooth-Derived Dentin
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- Okubo Naoto
- Laboratory of Molecular and Cellular Medicine, Faculty of Pharmaceutical Sciences, Hokkaido University
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- Ishikawa Masahiro
- Ishikawa Dental Clinic
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- Shakya Mamata
- Division of Oral Regenerative Medicine, School of Dentistry, Health Sciences University of Hokkaido
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- Hosono Hidetaka
- DeVine Inc.
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- Maehara Osamu
- Laboratory of Molecular and Cellular Medicine, Faculty of Pharmaceutical Sciences, Hokkaido University
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- Ohkawara Tatsuya
- Laboratory of Molecular and Cellular Medicine, Faculty of Pharmaceutical Sciences, Hokkaido University
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- Ohnishi Shunsuke
- Laboratory of Molecular and Cellular Medicine, Faculty of Pharmaceutical Sciences, Hokkaido University
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- Akazawa Toshiyuki
- Industrial Technology and Environment Research Development, Hokkaido Research Organization
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- Murata Masaru
- Division of Oral Regenerative Medicine, School of Dentistry, Health Sciences University of Hokkaido
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<p>Onlay bone augmentation is a challenging field, especially in esthetic zones. In implant dentistry, labial bone loss is generally recovered through autologous bone and/or biomaterials. Dental pioneers have been applying a patient-own demineralized dentin matrix (DDM) for bone regeneration. The aim of this study was to histologically and radiologically evaluate horizontal bone augmentation on an anterior atrophic maxilla using an autograft of non-vital tooth-derived DDM for implant. A 56-year-old female patient presented with severe labial bone loss. Autologous DDM was immediately prepared for horizontal ridge augmentation. DDM blocks were fixed with titanium screws for lateral augmentation. DDM granules were grafted on the atrophic bone between the DDM blocks. Twelve months postoperatively, bone biopsy was performed from the implant placement point for histological observation. X-ray computed tomography (CT) was performed before and after the DDM graft surgery. Hematoxylin and eosin sections showed that new bones were directly generated on the DDM residue. CT images showed the original buccal bone lines and root-type and wall-type DDM. The grafted DDMs were clearly found on the original bone. The outlines in the 22nd region indicated an 8.11 mm horizontal width after the implant placements compared to 4.95 mm before the augmentation. Additionally, the width at the upper level increased from 3.38 mm to 5.92 mm. DDM scaffolds contributed to the horizontal bony support required to place the implants. The patient experienced therapeutic success with DDM immediate autograft and implant surgery.</p>
収録刊行物
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- Journal of Hard Tissue Biology
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Journal of Hard Tissue Biology 31 (1), 47-54, 2022
硬組織再生生物学会
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詳細情報 詳細情報について
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- CRID
- 1390572404769011200
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- NII論文ID
- 130008149070
- 40022825707
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- NII書誌ID
- AA11074332
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- ISSN
- 1880828X
- 13417649
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- NDL書誌ID
- 031987668
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- KAKEN
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- 抄録ライセンスフラグ
- 使用不可