Prediction and clinical prognosis of histological chorioamnionitis using maternal serum CRP values in preterm rupture of membranes < 34 weeks

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  • OGINO-UEDA Nana
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • WAKIMOTO Yu
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • KAMEI Hidetake
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • KAMIHIGASHI Mariko
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • SUGIYAMA Yukiko
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • HARADA Kayoko
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • FUKUI Atsushi
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • SHIBAHARA Hiroaki
    Department of Obstetrics and Gynecology, Hyogo College of Medicine

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Other Title
  • 妊娠34週未満の前期破水症例における，母体血清CRP値による組織学的絨毛膜羊膜炎の予測と臨床的予後についての検討
  • ニンシン 34シュウ ミマン ノ ゼンキ ハスイ ショウレイ ニ オケル,ボタイ ケッセイ CRPチ ニ ヨル ソシキガクテキジュウモウマク ヨウマクエン ノ ヨソク ト リンショウテキ ヨゴ ニ ツイテ ノ ケントウ

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Abstract

<p>To reveal the relationship between maternal serum C-reactive protein (CRP) level pre-delivery and the presence of histological chorioamnionitis (hCAM). Sixty-one women with singleton pregnancies with previable premature rupture of the membranes (pPROM) occurring at <less than 34 weeks’ gestation were registered in this study. We retrospectively examined the relationship between perinatal factors associated with the prognoses of newborns and compared them between women with or without hCAM using medical records. We classified 61 patients with placental pathology based on Blanc’s classification . Women with hCAM grade III had significantly earlier rupture of membranes and deliveries (29 ± 4.6 weeks vs.vs 27 ± 3.0 weeks, p=0.048) (31 weeks vs. 28 weeks, p=0.003), significantly lower birth weights (1622±600 g vs. 1198±456 g, p=0.004), and significantly higher pre-delivery maternal serum CRP levels (1.3±1.4 mg/dl vs. 2.9±2.4 mg/dl, p=0.003) than women without hCAM III. In the ROC analysis for hCAM III onset in the maternal serum CRP value, the cutoff value was over 0.51 mg/dl and was extracted as a significant risk factor for hCAM III. The presence of hCAM III may be diagnosed based on maternal serum CRP levels 0.51 mg/dl. Therefore, the well-being of the infant, maternal fever, and infant tachycardia with elevated maternal serum CRP could indicate hCAM III. [Adv Obstet Gynecol, 74 (1) : 1-11, 2022 (R4.2)]</p>

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