A case report : development of hydatidiform mole coexistent with a fetus to clinically invasive mole with hypertensive disorders of pregnancy(HDP)

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  • HOSHINA Ryoma
    Department of Obstetrics and Gynecology, Osaka City University, Graduate School of Medicine
  • MISUGI Takuya
    Department of Obstetrics and Gynecology, Osaka City University, Graduate School of Medicine
  • TAHARA Mie
    Department of Obstetrics and Gynecology, Osaka City University, Graduate School of Medicine
  • HAMURO Akihiro
    Department of Obstetrics and Gynecology, Osaka City University, Graduate School of Medicine
  • NAKANO Akemi
    Department of Obstetrics and Gynecology, Osaka City University, Graduate School of Medicine
  • TACHIBANA Daisuke
    Department of Obstetrics and Gynecology, Osaka City University, Graduate School of Medicine
  • KOYAMA Masayasu
    Department of Obstetrics and Gynecology, Osaka City University, Graduate School of Medicine

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Other Title
  • 妊娠高血圧症候群を併発した胎児共存奇胎から臨床的侵入奇胎へ進展した1例
  • ニンシン コウケツアツ ショウコウグン オ ヘイハツ シタ タイジ キョウソンキタイ カラ リンショウテキ シンニュウキタイ エ シンテン シタ 1レイ

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<p>Hydatidiform mole coexistent with a fetus is a rare complication occurring in one in 22,000 to 100,000 pregnancies. In the case of a complete hydatidiform mole, the probability of a live birth is reported to be around 70% if the pregnancy can progress until 24 gestational weeks (GW) or later. We report a case of hydatidiform mole coexistent with a fetus and complicated with preeclampsia, thus resulting in termination. The patient was 39-years-old, unipara. At 12 GW, there was a multivesicular pattern lesion in the uterus, and her blood hCG level at 15 GW was 856,398.2 mIU/ml.Amniocentesis showed no chromosomal abnormalities, and the diagnosis of a complete hydatidiform mole was made. At 20 GW, the patient’s blood pressure was 158/72 mmHg, and urinalysis showed proteinuria 3+, thus indicating preeclampsia. At 21 GW, her blood pressure had risen 170/68 mmHg, and the pregnancy was terminated due to the risk of serious damage to maternal health. Labor was induced, and a female fetus and cystic lesion were delivered. Five weeks later, the patient’s blood hCG was 17,041.1 mIU/ml, so she underwent further testing. MRI showed a 5 cm mass in the pelvis, and we diagnosed a clinically invasive mole. Chemotherapy was subsequently administered. [Adv Obstet Gynecol, 74(1) : 179-187, 2022 (R4.2)]</p>

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